Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
Identifieur interne : 001989 ( Main/Exploration ); précédent : 001988; suivant : 001990Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
Auteurs : Zhongshu Tang ; Pachiappan Arjunan ; Chunsik Lee ; Yang Li ; Anil Kumar ; Xu Hou ; Bin Wang ; Piotr Wardega ; Fan Zhang ; Lijin Dong ; Yongqing Zhang ; Shi-Zhuang Zhang ; Hao Ding ; Robert N. Fariss ; Kevin G. Becker ; Johan Lennartsson ; Nobuo Nagai ; Yihai Cao ; Xuri LiSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2010.
Abstract
Platelet-derived growth factor CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report a novel finding that PDGF-CC is a potent neuroprotective factor that acts by modulating glycogen synthase kinase 3β (GSK3β) activity. In several different animal models of neuronal injury, such as axotomy-induced neuronal death, neurotoxin-induced neuronal injury, 6-hydroxydopamine–induced Parkinson’s dopaminergic neuronal death, and ischemia-induced stroke, PDGF-CC protein or gene delivery protected different types of neurons from apoptosis in both the retina and brain. On the other hand, loss-of-function assays using
Url:
DOI: 10.1084/jem.20091704
PubMed: 20231377
PubMed Central: 2856029
Affiliations:
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Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20231377</idno><idno type="pmc">2856029</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856029</idno><idno type="RBID">PMC:2856029</idno><idno type="doi">10.1084/jem.20091704</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000A18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A18</idno><idno type="wicri:Area/Pmc/Curation">000A18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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(NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Arjunan, Pachiappan" sort="Arjunan, Pachiappan" uniqKey="Arjunan P" first="Pachiappan" last="Arjunan">Pachiappan Arjunan</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Lee, Chunsik" sort="Lee, Chunsik" uniqKey="Lee C" first="Chunsik" last="Lee">Chunsik Lee</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Kumar, Anil" sort="Kumar, Anil" uniqKey="Kumar A" first="Anil" last="Kumar">Anil Kumar</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Hou, Xu" sort="Hou, Xu" uniqKey="Hou X" first="Xu" last="Hou">Xu Hou</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Wang, Bin" sort="Wang, Bin" uniqKey="Wang B" first="Bin" last="Wang">Bin Wang</name><affiliation><nlm:aff id="aff2"><institution>Department of Radiology, Medical Imaging Center of the Affiliated Hospital, Weifang Medical University, Weifang City, Shandong, 261053 China</institution></nlm:aff></affiliation></author><author><name sortKey="Wardega, Piotr" sort="Wardega, Piotr" uniqKey="Wardega P" first="Piotr" last="Wardega">Piotr Wardega</name><affiliation><nlm:aff id="aff3"><institution>Ludwig Institute for Cancer Research, Uppsala University, 751 24 Uppsala, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Dong, Lijin" sort="Dong, Lijin" uniqKey="Dong L" first="Lijin" last="Dong">Lijin Dong</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Zhang, Yongqing" sort="Zhang, Yongqing" uniqKey="Zhang Y" first="Yongqing" last="Zhang">Yongqing Zhang</name><affiliation><nlm:aff id="aff4"><institution>NIH Biomedical Research Center, National Institute on Aging, NIH, Baltimore, MD 21224</institution></nlm:aff></affiliation></author><author><name sortKey="Zhang, Shi Zhuang" sort="Zhang, Shi Zhuang" uniqKey="Zhang S" first="Shi-Zhuang" last="Zhang">Shi-Zhuang Zhang</name><affiliation><nlm:aff id="aff2"><institution>Department of Radiology, Medical Imaging Center of the Affiliated Hospital, Weifang Medical University, Weifang City, Shandong, 261053 China</institution></nlm:aff></affiliation></author><author><name sortKey="Ding, Hao" sort="Ding, Hao" uniqKey="Ding H" first="Hao" last="Ding">Hao Ding</name><affiliation><nlm:aff id="aff5"><institution>Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg MB R3E 3P5, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Fariss, Robert N" sort="Fariss, Robert N" uniqKey="Fariss R" first="Robert N." last="Fariss">Robert N. Fariss</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Becker, Kevin G" sort="Becker, Kevin G" uniqKey="Becker K" first="Kevin G." last="Becker">Kevin G. Becker</name><affiliation><nlm:aff id="aff4"><institution>NIH Biomedical Research Center, National Institute on Aging, NIH, Baltimore, MD 21224</institution></nlm:aff></affiliation></author><author><name sortKey="Lennartsson, Johan" sort="Lennartsson, Johan" uniqKey="Lennartsson J" first="Johan" last="Lennartsson">Johan Lennartsson</name><affiliation><nlm:aff id="aff3"><institution>Ludwig Institute for Cancer Research, Uppsala University, 751 24 Uppsala, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Nagai, Nobuo" sort="Nagai, Nobuo" uniqKey="Nagai N" first="Nobuo" last="Nagai">Nobuo Nagai</name><affiliation><nlm:aff id="aff6"><institution>Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511, Japan</institution></nlm:aff></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation><nlm:aff id="aff7"><institution>Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><affiliation><nlm:aff id="aff1"><institution>National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Platelet-derived growth factor CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report a novel finding that PDGF-CC is a potent neuroprotective factor that acts by modulating glycogen synthase kinase 3β (GSK3β) activity. In several different animal models of neuronal injury, such as axotomy-induced neuronal death, neurotoxin-induced neuronal injury, 6-hydroxydopamine–induced Parkinson’s dopaminergic neuronal death, and ischemia-induced stroke, PDGF-CC protein or gene delivery protected different types of neurons from apoptosis in both the retina and brain. On the other hand, loss-of-function assays using <italic>PDGF-C</italic> null mice, neutralizing antibody, or short hairpin RNA showed that PDGF-CC deficiency/inhibition exacerbated neuronal death in different neuronal tissues in vivo. Mechanistically, we revealed that the neuroprotective effect of PDGF-CC was achieved by regulating GSK3β phosphorylation and expression. Our data demonstrate that PDGF-CC is critically required for neuronal survival and may potentially be used to treat neurodegenerative diseases. Inhibition of the PDGF-CC–PDGF receptor pathway for different clinical purposes should be conducted with caution to preserve normal neuronal functions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aase, K" uniqKey="Aase K">K. Aase</name></author><author><name sortKey="Abramsson, A" uniqKey="Abramsson A">A. Abramsson</name></author><author><name sortKey="Karlsson, L" uniqKey="Karlsson L">L. Karlsson</name></author><author><name sortKey="Betsholtz, C" uniqKey="Betsholtz C">C. Betsholtz</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrae, J" uniqKey="Andrae J">J. Andrae</name></author><author><name sortKey="Gallini, R" uniqKey="Gallini R">R. Gallini</name></author><author><name sortKey="Betsholtz, C" uniqKey="Betsholtz C">C. Betsholtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, R" uniqKey="Cao R">R. Cao</name></author><author><name sortKey="Br Kenhielm, E" uniqKey="Br Kenhielm E">E. Bråkenhielm</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Pietras, K" uniqKey="Pietras K">K. Pietras</name></author><author><name sortKey="Widenfalk, J" uniqKey="Widenfalk J">J. Widenfalk</name></author><author><name sortKey="Ostman, A" uniqKey="Ostman A">A. Ostman</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimmeler, S" uniqKey="Dimmeler S">S. Dimmeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, H" uniqKey="Ding H">H. Ding</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Kim, I" uniqKey="Kim I">I. Kim</name></author><author><name sortKey="Tam, P P" uniqKey="Tam P">P.P. Tam</name></author><author><name sortKey="Koh, G Y" uniqKey="Koh G">G.Y. Koh</name></author><author><name sortKey="Nagy, A" uniqKey="Nagy A">A. Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, H" uniqKey="Ding H">H. Ding</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Bostrom, H" uniqKey="Bostrom H">H. Boström</name></author><author><name sortKey="Kim, I" uniqKey="Kim I">I. Kim</name></author><author><name sortKey="Wong, N" uniqKey="Wong N">N. Wong</name></author><author><name sortKey="Tsoi, B" uniqKey="Tsoi B">B. Tsoi</name></author><author><name sortKey="O Ourke, M" uniqKey="O Ourke M">M. O’Rourke</name></author><author><name sortKey="Koh, G Y" uniqKey="Koh G">G.Y. Koh</name></author><author><name sortKey="Soriano, P" uniqKey="Soriano P">P. Soriano</name></author><author><name sortKey="Betsholtz, C" uniqKey="Betsholtz C">C. Betsholtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fredriksson, L" uniqKey="Fredriksson L">L. Fredriksson</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Fieber, C" uniqKey="Fieber C">C. Fieber</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fredriksson, L" uniqKey="Fredriksson L">L. Fredriksson</name></author><author><name sortKey="Ehnman, M" uniqKey="Ehnman M">M. Ehnman</name></author><author><name sortKey="Fieber, C" uniqKey="Fieber C">C. Fieber</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbertson, D G" uniqKey="Gilbertson D">D.G. Gilbertson</name></author><author><name sortKey="Duff, M E" uniqKey="Duff M">M.E. Duff</name></author><author><name sortKey="West, J W" uniqKey="West J">J.W. West</name></author><author><name sortKey="Kelly, J D" uniqKey="Kelly J">J.D. Kelly</name></author><author><name sortKey="Sheppard, P O" uniqKey="Sheppard P">P.O. Sheppard</name></author><author><name sortKey="Hofstrand, P D" uniqKey="Hofstrand P">P.D. Hofstrand</name></author><author><name sortKey="Gao, Z" uniqKey="Gao Z">Z. Gao</name></author><author><name sortKey="Shoemaker, K" uniqKey="Shoemaker K">K. Shoemaker</name></author><author><name sortKey="Bukowski, T R" uniqKey="Bukowski T">T.R. Bukowski</name></author><author><name sortKey="Moore, M" uniqKey="Moore M">M. Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamada, T" uniqKey="Hamada T">T. Hamada</name></author><author><name sortKey="Ui Tei, K" uniqKey="Ui Tei K">K. Ui-Tei</name></author><author><name sortKey="Miyata, Y" uniqKey="Miyata Y">Y. Miyata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamada, T" uniqKey="Hamada T">T. Hamada</name></author><author><name sortKey="Ui Tei, K" uniqKey="Ui Tei K">K. Ui-Tei</name></author><author><name sortKey="Imaki, J" uniqKey="Imaki J">J. Imaki</name></author><author><name sortKey="Takahashi, F" uniqKey="Takahashi F">F. Takahashi</name></author><author><name sortKey="Onodera, H" uniqKey="Onodera H">H. Onodera</name></author><author><name sortKey="Mishima, T" uniqKey="Mishima T">T. Mishima</name></author><author><name sortKey="Miyata, Y" uniqKey="Miyata Y">Y. Miyata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heldin, C H" uniqKey="Heldin C">C.H. Heldin</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author><author><name sortKey="Ostman, A" uniqKey="Ostman A">A. Ostman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kazlauskas, A" uniqKey="Kazlauskas A">A. Kazlauskas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Y W" uniqKey="Lee Y">Y.W. Lee</name></author><author><name sortKey="Ozeki, M" uniqKey="Ozeki M">M. Ozeki</name></author><author><name sortKey="Juhn, S K" uniqKey="Juhn S">S.K. Juhn</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, H" uniqKey="Lei H">H. Lei</name></author><author><name sortKey="Kazlauskas, A" uniqKey="Kazlauskas A">A. Kazlauskas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, H" uniqKey="Lei H">H. Lei</name></author><author><name sortKey="Hovland, P" uniqKey="Hovland P">P. Hovland</name></author><author><name sortKey="Velez, G" uniqKey="Velez G">G. Velez</name></author><author><name sortKey="Haran, A" uniqKey="Haran A">A. Haran</name></author><author><name sortKey="Gilbertson, D" uniqKey="Gilbertson D">D. Gilbertson</name></author><author><name sortKey="Hirose, T" uniqKey="Hirose T">T. Hirose</name></author><author><name sortKey="Kazlauskas, A" uniqKey="Kazlauskas A">A. Kazlauskas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U. Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Ponten, A" uniqKey="Ponten A">A. Pontén</name></author><author><name sortKey="Aase, K" uniqKey="Aase K">K. Aase</name></author><author><name sortKey="Karlsson, L" uniqKey="Karlsson L">L. Karlsson</name></author><author><name sortKey="Abramsson, A" uniqKey="Abramsson A">A. Abramsson</name></author><author><name sortKey="Uutela, M" uniqKey="Uutela M">M. Uutela</name></author><author><name sortKey="B Ckstrom, G" uniqKey="B Ckstrom G">G. Bäckström</name></author><author><name sortKey="Hellstrom, M" uniqKey="Hellstrom M">M. Hellström</name></author><author><name sortKey="Bostrom, H" uniqKey="Bostrom H">H. Boström</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Tjwa, M" uniqKey="Tjwa M">M. Tjwa</name></author><author><name sortKey="Moons, L" uniqKey="Moons L">L. Moons</name></author><author><name sortKey="Fons, P" uniqKey="Fons P">P. Fons</name></author><author><name sortKey="Noel, A" uniqKey="Noel A">A. Noel</name></author><author><name sortKey="Ny, A" uniqKey="Ny A">A. Ny</name></author><author><name sortKey="Zhou, J M" uniqKey="Zhou J">J.M. Zhou</name></author><author><name sortKey="Lennartsson, J" uniqKey="Lennartsson J">J. Lennartsson</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Luttun, A" uniqKey="Luttun A">A. Luttun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Nagai, N" uniqKey="Nagai N">N. Nagai</name></author><author><name sortKey="Tang, Z" uniqKey="Tang Z">Z. Tang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Scotney, P" uniqKey="Scotney P">P. Scotney</name></author><author><name sortKey="Lennartsson, J" uniqKey="Lennartsson J">J. Lennartsson</name></author><author><name sortKey="Zhu, C" uniqKey="Zhu C">C. Zhu</name></author><author><name sortKey="Qu, Y" uniqKey="Qu Y">Y. Qu</name></author><author><name sortKey="Fang, C" uniqKey="Fang C">C. Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, M H" uniqKey="Liang M">M.H. Liang</name></author><author><name sortKey="Chuang, D M" uniqKey="Chuang D">D.M. Chuang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindholm, P" uniqKey="Lindholm P">P. Lindholm</name></author><author><name sortKey="Voutilainen, M H" uniqKey="Voutilainen M">M.H. Voutilainen</name></author><author><name sortKey="Lauren, J" uniqKey="Lauren J">J. Laurén</name></author><author><name sortKey="Per Nen, J" uniqKey="Per Nen J">J. Peränen</name></author><author><name sortKey="Lepp Nen, V M" uniqKey="Lepp Nen V">V.M. Leppänen</name></author><author><name sortKey="Andressoo, J O" uniqKey="Andressoo J">J.O. Andressoo</name></author><author><name sortKey="Lindahl, M" uniqKey="Lindahl M">M. Lindahl</name></author><author><name sortKey="Janhunen, S" uniqKey="Janhunen S">S. Janhunen</name></author><author><name sortKey="Kalkkinen, N" uniqKey="Kalkkinen N">N. Kalkkinen</name></author><author><name sortKey="Timmusk, T" uniqKey="Timmusk T">T. Timmusk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipton, S A" uniqKey="Lipton S">S.A. Lipton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nirmalananthan, N" uniqKey="Nirmalananthan N">N. Nirmalananthan</name></author><author><name sortKey="Greensmith, L" uniqKey="Greensmith L">L. Greensmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reigstad, L J" uniqKey="Reigstad L">L.J. Reigstad</name></author><author><name sortKey="Varhaug, J E" uniqKey="Varhaug J">J.E. Varhaug</name></author><author><name sortKey="Lillehaug, J R" uniqKey="Lillehaug J">J.R. Lillehaug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reisberg, B" uniqKey="Reisberg B">B. Reisberg</name></author><author><name sortKey="Doody, R" uniqKey="Doody R">R. Doody</name></author><author><name sortKey="Stoffler, A" uniqKey="Stoffler A">A. Stöffler</name></author><author><name sortKey="Schmitt, F" uniqKey="Schmitt F">F. Schmitt</name></author><author><name sortKey="Ferris, S" uniqKey="Ferris S">S. Ferris</name></author><author><name sortKey="Mobius, H J" uniqKey="Mobius H">H.J. Möbius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rieckmann, P" uniqKey="Rieckmann P">P. Rieckmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakata, M" uniqKey="Sakata M">M. Sakata</name></author><author><name sortKey="Yanamoto, H" uniqKey="Yanamoto H">H. Yanamoto</name></author><author><name sortKey="Hashimoto, N" uniqKey="Hashimoto N">N. Hashimoto</name></author><author><name sortKey="Iihara, K" uniqKey="Iihara K">K. Iihara</name></author><author><name sortKey="Tsukahara, T" uniqKey="Tsukahara T">T. Tsukahara</name></author><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T. Taniguchi</name></author><author><name sortKey="Kikuchi, H" uniqKey="Kikuchi H">H. Kikuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, M" uniqKey="Schwartz M">M. Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stambolic, V" uniqKey="Stambolic V">V. Stambolic</name></author><author><name sortKey="Woodgett, J R" uniqKey="Woodgett J">J.R. Woodgett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, E J" uniqKey="Su E">E.J. Su</name></author><author><name sortKey="Fredriksson, L" uniqKey="Fredriksson L">L. Fredriksson</name></author><author><name sortKey="Geyer, M" uniqKey="Geyer M">M. Geyer</name></author><author><name sortKey="Folestad, E" uniqKey="Folestad E">E. Folestad</name></author><author><name sortKey="Cale, J" uniqKey="Cale J">J. Cale</name></author><author><name sortKey="Andrae, J" uniqKey="Andrae J">J. Andrae</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name></author><author><name sortKey="Pietras, K" uniqKey="Pietras K">K. Pietras</name></author><author><name sortKey="Mann, K" uniqKey="Mann K">K. Mann</name></author><author><name sortKey="Yepes, M" uniqKey="Yepes M">M. Yepes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Andren, P E" uniqKey="Andren P">P.E. Andren</name></author><author><name sortKey="Svenningsson, P" uniqKey="Svenningsson P">P. Svenningsson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Arjunan, Pachiappan" sort="Arjunan, Pachiappan" uniqKey="Arjunan P" first="Pachiappan" last="Arjunan">Pachiappan Arjunan</name><name sortKey="Becker, Kevin G" sort="Becker, Kevin G" uniqKey="Becker K" first="Kevin G." last="Becker">Kevin G. Becker</name><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><name sortKey="Ding, Hao" sort="Ding, Hao" uniqKey="Ding H" first="Hao" last="Ding">Hao Ding</name><name sortKey="Dong, Lijin" sort="Dong, Lijin" uniqKey="Dong L" first="Lijin" last="Dong">Lijin Dong</name><name sortKey="Fariss, Robert N" sort="Fariss, Robert N" uniqKey="Fariss R" first="Robert N." last="Fariss">Robert N. Fariss</name><name sortKey="Hou, Xu" sort="Hou, Xu" uniqKey="Hou X" first="Xu" last="Hou">Xu Hou</name><name sortKey="Kumar, Anil" sort="Kumar, Anil" uniqKey="Kumar A" first="Anil" last="Kumar">Anil Kumar</name><name sortKey="Lee, Chunsik" sort="Lee, Chunsik" uniqKey="Lee C" first="Chunsik" last="Lee">Chunsik Lee</name><name sortKey="Lennartsson, Johan" sort="Lennartsson, Johan" uniqKey="Lennartsson J" first="Johan" last="Lennartsson">Johan Lennartsson</name><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><name sortKey="Nagai, Nobuo" sort="Nagai, Nobuo" uniqKey="Nagai N" first="Nobuo" last="Nagai">Nobuo Nagai</name><name sortKey="Tang, Zhongshu" sort="Tang, Zhongshu" uniqKey="Tang Z" first="Zhongshu" last="Tang">Zhongshu Tang</name><name sortKey="Wang, Bin" sort="Wang, Bin" uniqKey="Wang B" first="Bin" last="Wang">Bin Wang</name><name sortKey="Wardega, Piotr" sort="Wardega, Piotr" uniqKey="Wardega P" first="Piotr" last="Wardega">Piotr Wardega</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><name sortKey="Zhang, Shi Zhuang" sort="Zhang, Shi Zhuang" uniqKey="Zhang S" first="Shi-Zhuang" last="Zhang">Shi-Zhuang Zhang</name><name sortKey="Zhang, Yongqing" sort="Zhang, Yongqing" uniqKey="Zhang Y" first="Yongqing" last="Zhang">Yongqing Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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